SB 297006

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

SB 297006 是 CC 趋化因子受体 3 (CCR3；IC50 = 39 nM) 的拮抗剂，通常由嗜酸细胞趋化因子、嗜酸细胞趋化因子-3、MCP-3、MCP-4、RANTES 和 MIP-1δ 激活。

SB 297006 is an antagonist of C-C chemokine receptor 3 (CCR3; IC50 = 39 nM), which normally is activated by eotaxin, eotaxin-3, MCP-3, MCP-4, RANTES, and MIP-1δ. It is at least 250-fold selective for CCR3 over a panel of other chemokine receptors. SB 297006 blocks CCR3-mediated calcium mobilization induced by eotaxin, eotaxin-2, and MCP-4 in transfected cells. It suppresses antigen-induced accumulation of Th2 lymphocytes and eosinophils in lungs of mice when delivered subcutaneously (100 mg/kg).

SB297006 is a CCR3 antagonist, significantly inhibits proliferation and neurosphere formation in CCL11-treated neural progenitor cells (NPCs) at 100 μM.

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Autophagy

CCR

CCR3

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58816-69-6

342.4

C18H18N2O5

>98% (HPLC)

DMSO : 150 mg/mL 438.15 mM;H2O : < 0.1 mg/mL

O=[N+]([O-])c2ccc(C[C@H](NC(=O)c1ccccc1)C(=O)OCC)cc2

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(-20℃)

With Ice Pack

≥ 2 years